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Radionuclide fluoride-18 is produced by 18O(p,n)18F nuclear reaction in irradiating H2[18O] enriched water. The former fluoride-18 target system to this cyclotron, supplied by the cyclotron producer, The Efremov Institute, possesses insufficient productivity, not greater than 1 Ci of fluorine during 2 hour irradiation and also it doesn't allow achieving high radiochemical yields in producing radiopharmaceuticals due to contamination of irradiated water with metallic impurities from target body. To provide the radiopharmaceutical department of Russian Research Center for Radiology and Surgical Technologies with required amount of fluoride-18 radionuclide, the new target system has been designed and tested. This target system allows obtaining 5 Ci of fluoride-18 at beam current of 50 mkA during 2 hour irradiation and ensures minimum amount of metal contaminations and, hence, higher radiochemical yield (up to 90% decay corrected, F18-FDG).
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