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WEPH36 |
From Plate Screening to Artificial Intelligence: Innovative developments on PROXIMA 2A at Synchrotron SOLEIL |
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- D. Jeangerard, L. Ciccone, D.K. Desjardins, A. Le Jollec, M. Savko, W. E. Shepard
SOLEIL, Gif-sur-Yvette, France
- A. Haouz
Pasteur Institute, Crystallisation and X-ray Diffraction (PF6), Paris, France
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PROXIMA 2A is a high performance 3rd generation synchrotron beamline dedicated to X-ray micro-crystallography on biological macromolecules. Since opening in March 2013, the experimental station has hosted a large number of users who have collected vast amounts of X-ray diffraction images from literally thousands of crystals. In order to streamline the throughput, enhance performance and add functionality, a number of innovative developments have been launched on PROXIMA 2A. These cover all aspects of the beamline, from the practical to the visionary: such as the design, fabrication and implementation of a dedicated high-precision motorized stage to screen crystallization plates for in situ X-ray data collections, and the employment artificial intelligence and computer vision technologies for the detection of samples under liquid nitrogen. Other notable beamline projects include the addition of a vertical translation table for the EIGER X 9M detector to permit the acquisition of ultrahigh (0.6 Å) resolution X-ray data, the incorporation of a miniaturized YAG-coupled photodiode within a beamstop and the determination of the SOC of a recently added kappa arm to the goniometer.
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DOI • |
reference for this paper
※ https://doi.org/10.18429/JACoW-MEDSI2018-WEPH36
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