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TY - CONF AU - Prebys, E. AU - Abergel, R.J. AU - Casey, W.H. AU - Cebra, D.A. ED - Boland, Mark ED - Tanaka, Hitoshi ED - Button, David ED - Dowd, Rohan ED - Schaa, Volker RW ED - Tan, Eugene TI - Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron J2 - Proc. of IPAC2019, Melbourne, Australia, 19-24 May 2019 CY - Melbourne, Australia T2 - International Particle Accelerator Conference T3 - 10 LA - english AB - There is a great deal of interest in the medical community in the use of the alpha-emitter 211-At as a therapeutic isotope. Among other things, its 7.2 hour half life is long enough to allow for recovery and labeling, but short enough to avoid long term activity in patients. Unfortunately, the only practical technique for its production is to bombard a 209-Bi target with a ~29 MeV alpha beam, so it is not accessible to commercial isotope production facilities, which all use fixed energy proton beams. The US Department of Energy is therefore supporting the development of a "University Isotope Network" (UIN) to satisfy this need. Our prposoal is to retrofit the variable-energy, multi-species cyclotron at the Crocker Nuclear Laboratory at the University of California Davis with an internal Bi-209 target, such that we can put at least 100 uA of 29 MeV alpha particles on target without concerns about extraction efficiency. Using very conservative assumptions, we are confident we will be able to produce 60 mCi of 211-At in solution in an eight hour shift, which includes setup, exposure, and chemical recovery. This poster will cover the design of the target, as well as the required chemical processing and reliability upgrades. PB - JACoW Publishing CP - Geneva, Switzerland SP - 3564 EP - 3567 KW - target KW - cyclotron KW - operation KW - proton KW - extraction DA - 2019/06 PY - 2019 SN - 978-3-95450-208-0 DO - DOI: 10.18429/JACoW-IPAC2019-THPMP051 UR - http://jacow.org/ipac2019/papers/thpmp051.pdf ER -