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                - C. Ronsivalle, M.C. Carpanese, G. Messina, L. Picardi, S. Sandri
 
                       ENEA C.R. Frascati, Frascati (Roma), Italy 
                - M. Benassi, L. Strigari
 
                       IFO, Roma, Italy 
                - E. Cisbani, S.F. Frullani, V. Macellari
 
                       ISS, Rome, Italy 
                - C. Marino
 
                       ENEA Casaccia, Roma, Italy 
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            The TOP-IMPLART project, developed by ENEA, the Italian National Institute of Health (ISS) and Regina Elena National Cancer Institute-IFO-Rome is devoted to the realization of a proton therapy centre to be sited at IFO, based on a sequence of linear accelerators and designed with three treatment rooms: one with a 150 MeV beam for shallow tumors and two with a 230 MeV beam for deep tumors. The first part of the acronym remarks the heritage from the TOP Project developed in 1998-2005 by ISS and ENEA, whilst the second part (“Intensity Modulated Proton Linear Accelerator for RadioTherapy”) exploits the possibility to perform a highly conformational therapy based on spatial and intensity modulation of the beam. The segment up to 150 MeV, funded by the Italian “Regione Lazio” for 11M€ over four years, is under installation at ENEA-Frascati for its validation before the transfer to IFO. The low energy part is also used as a facility for radiobiology experiments in the framework of a satellite program foreseeing cells irradiation at 7 MeV with a vertical and horizontal beam and small animal irradiation with a 17.5 MeV horizontal beam. The status of the Project is presented.
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