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The ISIS Facility at the Rutherford Appleton Laboratory in the UK produces intense neutron and muon beams for condensed matter research. The ISIS 800 MeV Proton Synchrotron presently provides up to 2.5·1013 protons per pulse at 50 Hz, corresponding to a mean power of 160 kW. A dual harmonic RF system upgrade is expected to increase the intensity and power by about 50%. The tighter constraints expected for higher intensity running are motivating a detailed study of beam loss distributions and the main factors affecting their control. Main aims are maximising the localisation of activation in the collector straight, and minimising risk of damage to machine components. The combination of experimental work, developments of the loss measurement systems, and simulation studies are summarised. Key factors considered include: the effects of primary collector geometry and material; the nature of the beam loss; and methods for experimentally determining spatial loss distributions.
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